Intrinsic B cell TLR-BCR linked coengagement induces class-switched, hypermutated, neutralizing antibody responses in absence of T cells
Rivera C, Zhou Y, Chupp D, Yan H, Fisher A, Simon R, Zan H, Xu Z, Casali P. Intrinsic B cell TLR-BCR linked coengagement induces class-switched, hypermutated, neutralizing antibody responses in absence of T cells. The Journal Of Immunology 2023, 210: 60.08-60.08. DOI: 10.4049/jimmunol.210.supp.60.08.Peer-Reviewed Original ResearchClass switch DNA recombinationGeneration of memory B cellsAbsence of T cellsMemory B cellsT cell helpNeutralizing antibody responsesPlasma cell differentiationAntibody responseT cellsB cellsCell differentiationAnti-microbial responsesSomatic hypermutationT cell compartmentT cell functionAntibodies to E. coliDeclining T cell functionAffinity maturation processS. typhimuriumDNA recombinationMature antibody responseAnamnestic antibody responseLate-stage responsesSalmonella flagellinPhysical linkageRORα plays an important role in generation and maintenance of memory B cells
Xu Y, Moroney J, Zhou Y, Zan H, Casali P. RORα plays an important role in generation and maintenance of memory B cells. The Journal Of Immunology 2023, 210: 76.02-76.02. DOI: 10.4049/jimmunol.210.supp.76.02.Peer-Reviewed Original ResearchMemory B cellsMaintenance of memory B cellsB cellsNP-CGGAnti-NP antibody responseAnti-NP responsesClass-switched antibodiesAbstract Memory B cellsGerminal center formationActivated B cellsPlasma cell differentiationResponse to immunizationPlasma cellsAntigen-specificSecrete large amountsRNA-seq experimentsClass switch DNA recombinationClass switchingSomatic hypermutationMiceTranscriptional targetsCenter formationChromatin landscapeCell differentiationRNA-seqIntrinsic B cell TLR-BCR linked coengagement induces class-switched, hypermutated, neutralizing antibody responses in absence of T cells
Rivera C, Zhou Y, Chupp D, Yan H, Fisher A, Simon R, Zan H, Xu Z, Casali P. Intrinsic B cell TLR-BCR linked coengagement induces class-switched, hypermutated, neutralizing antibody responses in absence of T cells. Science Advances 2023, 9: eade8928. PMID: 37115935, PMCID: PMC10146914, DOI: 10.1126/sciadv.ade8928.Peer-Reviewed Original ResearchConceptsClass switch DNA recombinationT cell helpPlasma cell differentiationAntibody responseCell differentiationSomatic hypermutationGeneration of memory B cellsInduce neutralizing antibody responsesAbsence of T cellsMaturation of antibody responsesMemory B cellsNeutralizing antibody responsesResponse to NPDNA recombinationAnamnestic antibody responseMicrobial pathogensFlagellinT cellsB cellsClonal expansionClass switchingProtective antibodiesCoengagementCell receptorsDifferentiation
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