A humanized mouse that mounts mature class-switched, hypermutated and neutralizing antibody responses
Chupp D, Rivera C, Zhou Y, Xu Y, Ramsey P, Xu Z, Zan H, Casali P. A humanized mouse that mounts mature class-switched, hypermutated and neutralizing antibody responses. Nature Immunology 2024, 25: 1489-1506. PMID: 38918608, PMCID: PMC11291283, DOI: 10.1038/s41590-024-01880-3.Peer-Reviewed Original ResearchConceptsB cellsImmune cell differentiationAntibody responseHumanized micePfizer-BioNTech coronavirus disease 2019T cell antigen receptor repertoireFollicular helper T cellsGerminal center B cellsHuman cord blood CD34Human thymic epithelial cellsT cell-independent antibody responsesImmune systemMarginal zone B cellsMaturation of antibody responsesMemory B cell differentiationCD34+ cellsCord blood CD34Helper T cellsT cell-dependentThymic epithelial cellsNeutralizing antibody responsesB cell differentiationHuman B cellsAntigen receptor repertoireCell differentiation
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