2021
B2M overexpression correlates with malignancy and immune signatures in human gliomas
Zhang H, Cui B, Zhou Y, Wang X, Wu W, Wang Z, Dai Z, Cheng Q, Yang K. B2M overexpression correlates with malignancy and immune signatures in human gliomas. Scientific Reports 2021, 11: 5045. PMID: 33658560, PMCID: PMC7930032, DOI: 10.1038/s41598-021-84465-6.Peer-Reviewed Original ResearchMeSH Keywordsbeta 2-MicroglobulinBiomarkers, TumorBrain NeoplasmsCarcinogenesisCell Line, TumorDisease ProgressionGene Expression Regulation, NeoplasticGenomicsGliomaHumansImmune Checkpoint ProteinsImmune ToleranceImmunotherapyIsocitrate DehydrogenaseKaplan-Meier EstimateMutationPrognosisPTEN PhosphohydrolaseTumor MicroenvironmentConceptsB2M expressionImmune signaturesM expressionB2MAssociated with immune checkpoint moleculesAssociated with PTEN deletionSuppress anti-tumor immunityAnti-tumor immunityImmune checkpoint moleculesImmunotherapy of gliomaLimited treatment strategiesStromal cell typesCheckpoint moleculesEGFR amplificationClinical characteristicsPTEN deletionPatient prognosisTumor progressionTreatment strategiesGenomic profilingInflammatory activityImmunotherapySomatic mutationsCGGA databasesGlioma
2020
PDIA3 correlates with clinical malignant features and immune signature in human gliomas
Zhang H, Zhou Y, Cheng Q, Dai Z, Wang Z, Liu F, Fan F, Cui B, Cao H. PDIA3 correlates with clinical malignant features and immune signature in human gliomas. Aging 2020, 12: 15392-15413. PMID: 32687065, PMCID: PMC7467394, DOI: 10.18632/aging.103601.Peer-Reviewed Original ResearchConceptsProtein disulfide isomerase family A member 3Suppression of anti-tumor immunityImmune checkpoint inhibitorsAnti-tumor immunityAmplification of EGFRLoss of PTENImmune regulatory processesAssociated with inflammationStromal cell typesCheckpoint inhibitorsTreatment of gliomaImmune signaturesTumor microenvironmentT cellsMalignant featuresImmune targetsGenomic profilingTherapeutic strategiesSomatic mutationsInvestigated expressionGliomaCGGA databasesHuman gliomasClinical practiceProcess of glioma
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply