Intrinsic B cell TLR-BCR linked coengagement induces class-switched, hypermutated, neutralizing antibody responses in absence of T cells
Rivera C, Zhou Y, Chupp D, Yan H, Fisher A, Simon R, Zan H, Xu Z, Casali P. Intrinsic B cell TLR-BCR linked coengagement induces class-switched, hypermutated, neutralizing antibody responses in absence of T cells. The Journal Of Immunology 2023, 210: 60.08-60.08. DOI: 10.4049/jimmunol.210.supp.60.08.Peer-Reviewed Original ResearchClass switch DNA recombinationGeneration of memory B cellsAbsence of T cellsMemory B cellsT cell helpNeutralizing antibody responsesPlasma cell differentiationAntibody responseT cellsB cellsCell differentiationAnti-microbial responsesSomatic hypermutationT cell compartmentT cell functionAntibodies to E. coliDeclining T cell functionAffinity maturation processS. typhimuriumDNA recombinationMature antibody responseAnamnestic antibody responseLate-stage responsesSalmonella flagellinPhysical linkage
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