2025
Engineering Mice to Study Human Immunity.
Sefik E, Xiao T, Chiorazzi M, Odell I, Zhang F, Agrawal K, Micevic G, Flavell R. Engineering Mice to Study Human Immunity. Annual Review Of Immunology 2025 PMID: 40020225, DOI: 10.1146/annurev-immunol-082523-124415.Peer-Reviewed Original ResearchHumanized miceHuman hematopoiesisImmune responseImmune systemHumanized mouse modelHuman hematopoietic stemImmunocompromised murine hostsResident immune cellsHuman immune responseStudy human immunityHuman immune systemIntegration of multi-omicsHematopoietic stemImmune cell growthImmune cellsEngineered miceProgenitor cellsMouse modelImmunological diseasesMurine hostCancer treatmentPreclinical drugsHuman immunityMiceModel disease
2023
New insights into programmed cell death protein 1 blockade-associated cutaneous immune-related adverse events
Micevic G, Daniels A, Flavell R. New insights into programmed cell death protein 1 blockade-associated cutaneous immune-related adverse events. British Journal Of Dermatology 2023, 189: 355-357. PMID: 37471669, PMCID: PMC10503525, DOI: 10.1093/bjd/ljad236.Peer-Reviewed Original ResearchConceptsCutaneous immune-related adverse eventsImmune-related adverse eventsSelf-reactive T cellsCheckpoint receptor PD-1PD-1 inhibitorsHalf of patientsImmune checkpoint blockadeAntitumor immune responseReceptor PD-1Adverse eventsCheckpoint blockadePD-1Immune toleranceCTLA-4T cellsImmune responseLandmark studiesMolecular mechanismsFunctional roleCritical functional rolePatientsBlockadeDermatologistsImportant clues
2013
Inflammasomes and Mucosal Immune Response
Elinav E, Henao-Mejia J, Flavell R. Inflammasomes and Mucosal Immune Response. Else Kröner-Fresenius Symposia 2013, 4: 48-52. DOI: 10.1159/000346510.Peer-Reviewed Original ResearchProtein complexesImmune responseDamage signalsCritical regulatorMolecular characterizationContext of infectionInnate immune responseCell deathMucosal immune responsesMicrobial infectionsPotent inflammatory cytokineCaspase-1Direct activationInflammatory cytokinesSterile inflammationMetabolic disordersInflammasome resultsDiverse rangeInflammasomeKey componentRegulatorInfectionProteinNLRC4AIM2
2010
Human Interleukin-3/Granulocyte Macrophage-Colony Stimulating Factor Knock-In Mice Support Human Myeloid Cell Reconstitution and Human Immune Responses In the Lung.
Willinger T, Rongvaux A, Takizawa H, Eynon E, Stevens S, Manz M, Flavell R. Human Interleukin-3/Granulocyte Macrophage-Colony Stimulating Factor Knock-In Mice Support Human Myeloid Cell Reconstitution and Human Immune Responses In the Lung. Blood 2010, 116: 3789. DOI: 10.1182/blood.v116.21.3789.3789.Peer-Reviewed Original ResearchHuman immune responsePulmonary alveolar proteinosisImmune responseHuman myeloid cellsKI miceCell reconstitutionMyeloid cellsEnhanced systemic inflammatory responseFunctional human immune systemGM-CSFStrong innate immune responseSystemic inflammatory responseInfluenza virus infectionIL-3Human immune cellsInnate immune responseNew mouse modelHuman alveolar macrophagesHuman immune systemGranulocyte-macrophage colonyPAP syndromeHumanized miceAlveolar proteinosisImmune cellsInflammatory response
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