Pluripotent stem cell-derived interneuron progenitors mature and restore memory deficits but do not suppress seizures in the epileptic mouse brain
Anderson NC, Van Zandt MA, Shrestha S, Lawrence DB, Gupta J, Chen CY, Harrsch FA, Boyi T, Dundes CE, Aaron G, Naegele JR, Grabel L. Pluripotent stem cell-derived interneuron progenitors mature and restore memory deficits but do not suppress seizures in the epileptic mouse brain. Stem Cell Research 2018, 33: 83-94. PMID: 30340090, DOI: 10.1016/j.scr.2018.10.007.Peer-Reviewed Original ResearchConceptsTemporal lobe epilepsyInterneuron progenitorsHippocampal-dependent spatial memory deficitsMemory deficitsMorris water maze testEpileptic mouse brainMature firing patternMature GABAergic interneuronsWater maze testSpatial memory deficitsGABAergic interneuron dysfunctionHippocampus of rodentsInterneuron dysfunctionLobe epilepsySuppress seizuresGABAergic interneuronsMaze testSeizure suppressionMouse modelMouse brainFiring patternsSeizuresTransplantMiceStem cells
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