Sequential and parallel testing for microbiological confirmation of tuberculosis disease in children in five low-income and middle-income countries: a secondary analysis of the RaPaed-TB study
Olbrich L, Franckling-Smith Z, Larsson L, Sabi I, Ntinginya N, Khosa C, Banze D, Nliwasa M, Corbett E, Semphere R, Verghese V, Michael J, Ninan M, Saathoff E, McHugh T, Razid A, Graham S, Song R, Nabeta P, Trollip A, Nicol M, Hoelscher M, Geldmacher C, Heinrich N, Zar H, consortium R, Dalgarno C, Mtafya B, Mwambola H, Manyama C, Sudi L, Sichone E, Mapamba D, Olomi W, Edwin P, Chacko A, Kumari R, Krishnan D, Munisamy N, Mani D, Maueia C, Madeira C, Kachere D, Chinoko T, Sikwese T, Mnyanga A, Chiume L, Mantsoki A, Baard C, Munro J, Prins M, Benzi N, Bateman L, Ryan A, Booi K, Paulo N, Heydenrych A, Petersen W, Brookes R, Mento M, Centner C. Sequential and parallel testing for microbiological confirmation of tuberculosis disease in children in five low-income and middle-income countries: a secondary analysis of the RaPaed-TB study. The Lancet Infectious Diseases 2024, 25: 188-197. PMID: 39312914, DOI: 10.1016/s1473-3099(24)00494-8.Peer-Reviewed Original ResearchMicrobiological confirmationInduced sputumSpontaneous sputumM tuberculosisSecondary analysisMicrobiological resultsGerman Center for Infection ResearchAnti-tuberculosis medicationsXpert MTB/RIF UltraHigh-risk subgroupsDiagnostic accuracy studiesSpecimen typesHealth-care centresUK Medical Research CouncilMiddle-income countriesNasopharyngeal aspiratesExtrapulmonary tuberculosisMedian agePaediatric tuberculosisPositive culturesGastric aspiratesSputumLowenstein-JensenMedical Research CouncilChoice of tests
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