Long-Term Engraftment of Cryopreserved Human Neurons for In Vivo Disease Modeling in Neurodegenerative Disease
Marmion D, Deng P, Hiller B, Lewis R, Harms L, Cameron D, Nolta J, Kordower J, Fink K, Wakeman D. Long-Term Engraftment of Cryopreserved Human Neurons for In Vivo Disease Modeling in Neurodegenerative Disease. Biology 2025, 14: 217. PMID: 40001985, PMCID: PMC11852092, DOI: 10.3390/biology14020217.Peer-Reviewed Original ResearchCentral nervous systemStriatum of Sprague-Dawley ratsForebrain GABAergic neuronsLong-term engraftmentHuman induced pluripotent stem cellsHuman neuronsSprague-Dawley ratsWild-type controlsPluripotent stem cellsPrefrontal cortexMature neuronal phenotypeRNU ratsHost striatumDisease in vivoGABAergic neuronsPost-transplantationImmunodeficient ratsIn vivo disease modelsIGABAHuntington's diseaseCynomolgus monkeysNeuronal phenotypeHD miceCNS environmentNeuronal survival
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