2024
Foxp3+ regulatory T cells reside within the corneal epithelium and co-localize with limbal stem cells
Tahvildari M, Me R, Setia M, Gao N, Suvas P, McClellan S, Suvas S. Foxp3+ regulatory T cells reside within the corneal epithelium and co-localize with limbal stem cells. Experimental Eye Research 2024, 249: 110123. PMID: 39396695, PMCID: PMC11622170, DOI: 10.1016/j.exer.2024.110123.Peer-Reviewed Original ResearchConceptsLimbal stem cellsRegulatory T cellsResident TregsT cellsFoxp3<sup>+</sup> regulatory T cellsLimbal stem cell functionMouse modelCorneal epithelial wound healingModel of mechanical injuryStem cellsDepletion of TregsCell functionEpithelial wound healingEpithelial cell functionWound healingStem cell functionMechanical injuryAnti-CD25Epithelial healingSubconjunctival injectionCorneal epitheliumCorneal stromaTregsCornealCornea
2022
Amplified Natural Killer Cell Activity and Attenuated Regulatory T-cell Function Are Determinants for Corneal Alloimmunity in Very Young Mice
Nakao T, Inomata T, Blanco T, Musayeva A, Tahvildari M, Amouzegar A, Yin J, Chauhan S, Chen Y, Dana R. Amplified Natural Killer Cell Activity and Attenuated Regulatory T-cell Function Are Determinants for Corneal Alloimmunity in Very Young Mice. Transplantation 2022, 107: 1302-1310. PMID: 36584368, PMCID: PMC10205651, DOI: 10.1097/tp.0000000000004424.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCorneaCorneal TransplantationGraft RejectionInterferon-gammaKiller Cells, NaturalMiceMice, Inbred BALB CMice, Inbred C57BLT-Lymphocytes, RegulatoryConceptsNK cell depletionAllograft survivalNatural killerNK cellsGraft survivalYounger recipientsRejection of corneal allograftsSuppressing NK cell responsesSuppressive function of TregsCell depletionActivity of NK cellsIn vitro suppression assaySecretion of interferon-gammaRegulatory T cell functionFlow cytometryNatural killer cell activityAllogeneic corneal transplantationCorneal allograft survivalCorneal transplant outcomesYoung graft recipientsFrequency of TregsNK cell responsesRegulatory T cellsFunction of TregsActivated natural killer
2019
Low-Dose IL-2 Therapy in Transplantation, Autoimmunity, and Inflammatory Diseases.
Tahvildari M, Dana R. Low-Dose IL-2 Therapy in Transplantation, Autoimmunity, and Inflammatory Diseases. The Journal Of Immunology 2019, 203: 2749-2755. PMID: 31740549, PMCID: PMC6986328, DOI: 10.4049/jimmunol.1900733.Peer-Reviewed Original ResearchAnimalsAutoimmune DiseasesAutoimmunityGraft RejectionHumansImmunotherapyInflammationInterleukin-2T-Lymphocytes, RegulatoryLocal Delivery of Regulatory T Cells Promotes Corneal Allograft Survival
Shao C, Chen Y, Nakao T, Amouzegar A, Yin J, Tahvildari M, LuĹľnik Z, Chauhan S, Dana R. Local Delivery of Regulatory T Cells Promotes Corneal Allograft Survival. Transplantation 2019, 103: 182-190. PMID: 30247445, PMCID: PMC6309927, DOI: 10.1097/tp.0000000000002442.Peer-Reviewed Original Research
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