Compromised Cardiopulmonary Function in Fibulin-5 Deficient Mice.
Ramachandra AB, Mikush N, Sauler M, Humphrey JD, Manning EP. Compromised Cardiopulmonary Function in Fibulin-5 Deficient Mice. Journal Of Biomechanical Engineering 2022, 144 PMID: 35171214, PMCID: PMC8990734, DOI: 10.1115/1.4053873.Peer-Reviewed Original ResearchConceptsRight heart functionDeficient micePulmonary arteryHeart functionCompromised right ventricular functionFibulin-5 deficient micePulmonary arterial structureRight ventricular functionVentilation-perfusion relationshipsElastic fiber contentElastic fibersFiber dysfunctionLung compliancePulmonary healthVentricular functionCardiopulmonary functionAlveolar disruptionPulmonary pathologyLung parenchymaMurine modelMouse modelArterial structureHistological quantificationElastic laminaRight circulation
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